Alain Vande Wouwer has research activities in line with the current trend of Industry 4.0 and the development of hybrid digital twins combining mathematical modeling and data-based learning. In particular, he is interested in the dynamics of nonlinear systems, in parameter and state estimation techniques, in model-based control, or on the contrary in model-free control (extremum seeking control). His research is developing in different fields of application, including biotechnology and the bioindustries, the environment, mobile robotics and drones.