The researches of the laboratory focus on the cellular and molecular mechanisms of glutamatergic synaptic plasticity in the central nervous system in health and disease. Our approach consists of a combination of electrophysiological, molecular and cellular approaches. We develop and apply state-of-the-art electrophysiogical techniques. We combine this physiological read-out with behavioral measurements, immunohistochemistry and proteome analysis. We worked on normal mice and on animal models of disease, such as Alzheimer’s disease, auto-immune diseases or dopamine-related disorders.